一文读懂AD及痴呆的营养代谢和脑生物能学进展（综述）

Alzheimer's and Dementia[IF:16.655]

① 葡萄糖代谢失调、线粒体FAO损伤、细胞生物能衰竭及血脑屏障（BBB）功能障碍等是AD患者认知功能下降原因；

② BBB生物能量衰竭与脑细胞炎症和氧化应激有关，会引起髓鞘丧失及AD病理标志物出现，肠菌及其代谢物可能在AD患者相关衰老和线粒体功能障碍中发挥重要作用；

③ 线粒体功能障碍会导致向大脑输送营养紊乱，引起大脑生物能学营养支持不足提前发生，早于AD病理标志物出现；

④ 单一营养素或与饮食模式组合干预可指导AD个性化临床。

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias
12-08, doi: 10.1002/alz.12845

【主编评语】大脑满足其能量需求的能力受到干扰会增加突触丧失、神经退化和认知能力下降的风险。因此，针对代谢途径的营养和代谢干预与诊断相结合以识别脑生物能学缺陷可能为阿尔茨海默病 (AD) 的预防和管理提供新的治疗潜力。近日，美国南加州大学研究人员在Alzheimer's and Dementia上发表最新综述，系统论述了营养代谢在调节脑生物能和降低AD风险中的作用，在细胞水平上剖析了老化大脑中生物能量分解的主要机制，以及生物能量紊乱的假定原因和后果，特别是在血脑屏障与营养脑输送和营养干预的影响，还提出了单一营养素或与饮食模式组合干预AD的潜力，值得关注。

Nutritional metabolism and cerebral bioenergetics in Alzheimer's disease and related dementias

阿尔茨海默病及相关痴呆的营养代谢和脑生物能学

10.1002/alz.12845

12-08, Review

Abstract:

Disturbances in the brain's capacity to meet its energy demand increase the risk of synaptic loss, neurodegeneration, and cognitive decline. Nutritional and metabolic interventions that target metabolic pathways combined with diagnostics to identify deficits in cerebral bioenergetics may therefore offer novel therapeutic potential for Alzheimer's disease (AD) prevention and management. Many diet-derived natural bioactive components can govern cellular energy metabolism but their effects on brain aging are not clear. This review examines how nutritional metabolism can regulate brain bioenergetics and mitigate AD risk. We focus on leading mechanisms of cerebral bioenergetic breakdown in the aging brain at the cellular level, as well as the putative causes and consequences of disturbed bioenergetics, particularly at the blood-brain barrier with implications for nutrient brain delivery and nutritional interventions. Novel therapeutic nutrition approaches including diet patterns are provided, integrating studies of the gut microbiome, neuroimaging, and other biomarkers to guide future personalized nutritional interventions.

First Authors:
Hussein N Yassine

Correspondence Authors:
Hussein N Yassine

All Authors:
Hussein N Yassine,Wade Self,Bilal E Kerman,Giulia Santoni,NandaKumar Navalpur Shanmugam,Laila Abdullah,Lesley R Golden,Alfred N Fonteh,Michael G Harrington,Johannes Gräff,Gary E Gibson,Raj Kalaria,Jose A Luchsinger,Howard H Feldman,Russell H Swerdlow,Lance A Johnson,Benedict C Albensi,Berislav V Zlokovic,Rudolph Tanzi,Stephen Cunnane,Cécilia Samieri,Nikolaos Scarmeas,Gene L Bowman,Nutrition， Metabolism and Dementia PIA，Alzheimer's Association ISTAART