重庆大学：益生菌脂质前药涂层或可增强UC的靶向治疗？

Advanced Science[IF:17.521]

① 由脂质前药组成的涂层可赋予鼠李糖乳杆菌GG（LGG）较好的抵抗肠胃消化液能力，以维持其生物活性；

② 体外实验中，前药涂层在Caco-2细胞中具有优异的抗炎能力，且体内实验发现改造后的LGG比天然LGG表现出更强的定植能力；

③ 进入结肠后，前药在偶氮还原酶作用下会释放5-氨基水杨酸，抑制结肠炎症，为LGG定植提供良好的微环境；

④ 前药涂层有利于LGG肠道定植，并且调节肠道微生物群，从而改善上皮屏障功能，最终协同改善结肠炎病变。

Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis
12-11, doi: 10.1002/advs.202205422

【主编评语】溃疡性结肠炎（UC）影响着全球数百万患者，与肠道菌群紊乱有关，多项研究发现益生菌可通过调节肠道微生物群落结构及组成有效改善UC症状，但口服益生菌制剂存在生物活性有限、滞留时间短、病理情况复杂、治疗效果单一等问题。近日，重庆大学吴伟、秦弦、Kai Qu及团队在Advanced Science发表最新研究，利用含脂质前药组成的涂层保护LGG，不仅可提高LGG在体内的定植能力，而且还能调节肠道菌群和肠粘膜屏障改善小鼠结肠炎，值得关注。

Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis

益生菌前药涂层可增强溃疡性结肠炎的靶向治疗

10.1002/advs.202205422

12-11, Article

Abstract:
Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics-based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for UC. However, oral probiotics delivery is restricted by limited bioactivity, short retention time, complex pathological condition, and single therapeutic efficacy. Here, a bioengineered probiotic decorated with a multifunctional prodrug coating is constructed to ameliorate the aforementioned shortcomings. The results of UC mice induced by dextran sulfate sodium demonstrate that the intrinsic features of the fabricated coating integrate gut microbes protection, colon-targeted drug release, prolonged drug retention, and inflammation regulation. In parallel, the probiotics Lactobacillus rhamnosus GG (LGG) could regulate the composition of the gut microbiota and improve epithelial barrier function, thereby synergistically ameliorating UC. These results provide ample shreds of evidence of the therapeutic effect on UC, therefore, demonstrate a great promise as the potential therapeutic strategy for UC treatment.

First Authors:
Kun Zhang

Correspondence Authors:
Kai Qu,Xian Qin,Wei Wu

All Authors:
Kun Zhang,Li Zhu,Yuan Zhong,Lixin Xu,Chunhui Lang,Jian Chen,Fei Yan,Jiawei Li,Juhui Qiu,Yidan Chen,Da Sun,Guixue Wang,Kai Qu,Xian Qin,Wei Wu