国内团队：受益生菌启发的纳米药物或可缓解结肠炎

Advanced Materials[IF:32.086]

① 设计了一种生物人工益生菌可通过调节氧化还原平衡、免疫反应和肠道菌群来恢复结肠炎患者的肠道微环境；

② 借助超声法将大肠杆菌Nissle 1917衍生膜（EM）涂抹到可降解的二硒化胺桥接介孔二氧化硅纳米颗粒（SeM）形成仿生纳米药物（SeM@EM）；

③ DSS诱导构建小鼠结肠炎模型，口服SeM@EM可强烈地粘附在小鼠黏液层，有效调节肠道氧化还原平衡和免疫稳态；

④ 口服SeM@EM可调节小鼠肠道菌群多样性和组成，提高抗炎菌属丰度，进而缓解结肠炎。

Probiotic-inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the gut microbiome
11-07, doi: 10.1002/adma.202207890

【主编评语】基于微生物疗法为炎症性肠病（IBD）的治疗提供了新策略，然而，到目前为止较差的临床结果和有限灵活性的细菌方法仍需要改进。近日，国家纳米科学中心聂广军、美国哥伦比亚大学生物医学工程系Kam W Leong（梁锦荣）、华南理工大学邵丹、中国科学院大学纳米科学与技术学院张银龙及团队在Advanced Materials发表最新研究，受益生菌在缓解肠道疾病症状方面的健康益处启发，将大肠杆菌Nissle 1917衍生膜涂抹到可降解的二硒化胺桥接介孔二氧化硅纳米颗粒形成仿生纳米药物（SeM@EM）。构建结肠炎动物模型，发现口服SeM@EM可通过调节氧化还原平衡、免疫反应和肠道菌群来恢复结肠炎的肠道稳态。总之，该研究提出了一种基于益生菌膜治疗IBD的方法，也为未来开发类似的模拟益生菌纳米药物治疗胃肠道疾病提供了新思路。

Probiotic-inspired nanomedicine restores intestinal homeostasis in colitis by regulating redox balance, immune responses, and the gut microbiome

益生菌启发的纳米药物通过调节氧化还原平衡、免疫反应和肠道微生物组来恢复结肠炎的肠道稳态

10.1002/adma.202207890

11-07, Article

Abstract:

Microbiota-based therapeutics offer innovative strategies to treat inflammatory bowel diseases (IBDs). However, the poor clinical outcome so far and the limited flexibility of the bacterial approach call for improvement. Inspired by the health benefits of probiotics in alleviating symptoms of bowel diseases, we designed bioartificial probiotics to restore the intestinal microenvironment in colitis by regulating redox balance, immune responses, and the gut microbiome. The bioartificial probiotic comprises two components: an E. coli Nissle 1917-derived membrane (EM) as the surface and the biodegradable diselenide-bridged mesoporous silica nanoparticles (SeM) as the core. When orally administered, the probiotic-inspired nanomedicine (SeM@EM) adhered strongly to the mucus layer and restored intestinal redox balance and immune regulation homeostasis in a murine model of acute colitis induced by dextran sodium sulfate. In addition, the respective properties of the EM and SeM synergistically altered the gut microbiome to a favorable state by increasing the bacterial diversity and shifting the microbiome profile to an anti-inflammatory phenotype. This work suggests a safe and effective nanomedicine that can restore intestinal homeostasis for IBDs therapy.

First Authors:
Jiaqi Xu

Correspondence Authors:
Yinlong Zhang,Dan Shao,Kam W Leong,Guangjun Nie

All Authors:
Jiaqi Xu,Junchao Xu,Tongfei Shi,Yinlong Zhang,Fangman Chen,Chao Yang,Xinjing Guo,Guangna Liu,Dan Shao,Kam W Leong,Guangjun Nie