益生菌对肌肉质量、强度和总瘦质量有何影响？（荟萃分析）

Journal of Cachexia, Sarcopenia and Muscle[IF:12.063]

① 纳入24项随机对照试验（RCTs），评估益生菌对成人肌肉质量、总瘦质量和肌肉强度的影响；

② 与安慰剂组相比，服用益生菌后肌肉质量得到改善，但对总瘦质量无有益影响；

③ 其中6项RCTs观察到补充益生菌能显著增加全身肌肉强度；

④ 益生菌干预能增加肌肉质量，对于平均年龄50岁以下，持续时间较长（≥12周）、特别是补充双歧杆菌和亚洲个体均有效；

⑤ 补充益生菌对50岁及以上并遵循长期方案（≥12周）的个体整体肌肉力量更有效。

Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta-analysis of randomized controlled trials
11-22, doi: 10.1002/jcsm.13132

【主编评语】益生菌已显示出对抗肌少症的潜力，但它们对人体肌肉量和力量等肌少症症状影响程度尚不清楚。近日，英国利物浦大学研究人员在Journal of Cachexia, Sarcopenia and Muscle上发表最新研究，最终纳入24项随机对照试验，评估益生菌对成人肌肉质量、总瘦质量和肌肉强度的影响，发现益生菌干预可以增加肌肉质量，亚组分析也支持这一点（即对于平均年龄50岁以下，持续时间超过12周、特别是补充双歧杆菌和亚洲个体均有效）。总之，该研究为未来靶向菌群制定更合理的干预措施提供了支撑。 

Impact of probiotics on muscle mass, muscle strength and lean mass: a systematic review and meta-analysis of randomized controlled trials

益生菌对肌肉质量、肌肉强度和瘦质量的影响：随机对照试验的系统综述和荟萃分析

10.1002/jcsm.13132

11-22, Systemic Review & Meta-analysis

Abstract:
Probiotics have shown potential to counteract sarcopenia, although the extent to which they can influence domains of sarcopenia such as muscle mass and strength in humans is unclear. The aim of this systematic review and meta-analysis was to explore the impact of probiotic supplementation on muscle mass, total lean mass and muscle strength in human adults. A literature search of randomized controlled trials (RCTs) was conducted through PubMed, Scopus, Web of Science and Cochrane Library from inception until June 2022. Eligible RCTs compared the effect of probiotic supplementation versus placebo on muscle and total lean mass and global muscle strength (composite score of all muscle strength outcomes) in adults (>18 years). To evaluate the differences between groups, a meta-analysis was conducted using the random effects inverse-variance model by utilizing standardized mean differences. Twenty-four studies were included in the systematic review and meta-analysis exploring the effects of probiotics on muscle mass, total lean mass and global muscle strength. Our main analysis (k = 10) revealed that muscle mass was improved following probiotics compared with placebo (SMD: 0.42, 95% CI: 0.10–0.74, I2 = 57%, P = 0.009), although no changes were revealed in relation to total lean mass (k = 12; SMD: -0.03, 95% CI: −0.19 – 0.13, I2 = 0%, P = 0.69). Interestingly, a significant increase in global muscle strength was also observed among six RCTs (SMD: 0.69, 95% CI: 0.33–1.06, I2 = 64%, P = 0.0002). Probiotic supplementation enhances both muscle mass and global muscle strength; however, no beneficial effects were observed in total lean mass. Investigating the physiological mechanisms underpinning different ageing groups and elucidating appropriate probiotic strains for optimal gains in muscle mass and strength are warranted.

First Authors:
Konstantinos Prokopidis

Correspondence Authors:
Konstantinos Prokopidis

All Authors:
Konstantinos Prokopidis,Panagiotis Giannos,Richard Kirwan,Theocharis Ispoglou,Francesco Galli,Oliver C Witard,Konstantinos K Triantafyllidis,Konstantinos S Kechagias,Jordi Morwani-Mangnani,Andrea Ticinesi,Masoud Isanejad