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IL-17A缺陷小鼠,抵抗高脂饮食引起的肥胖

时间:2017-08-08 16:06来源:热心肠日报 作者:沈志勋 浏览次数:
    原标题:IL-17A依赖性肠道菌群对调节饮食诱导的小鼠紊乱是必需的

    ① 不同于野生型小鼠,给IL-17A缺陷型小鼠喂食高脂饮食(HFD),并不会出现肥胖及糖尿病等相关疾病;

    ② 将野生型小鼠与IL-17A缺陷型小鼠共同培养,可显著缓解前者的肥胖相关症状;

    ③ 两组小鼠的菌群组成在喂食HFD前即很不同,而在喂食后发生与小鼠表型有关的变化;

    ④ 在HFD诱导小鼠肥胖的过程中,分别存在起保护及伤害作用的菌种,两组小鼠的代谢通路均发生变化;

    ⑤ IL-17A对塑造和调节小鼠肠道菌群并进而影响宿主健康至关重要。

图片
Science Bulletin
[IF:4.000]
IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice
DOI: 10.1016/j.scib.2017.07.011
Abstract:
The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A (IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet (HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Il-17a-/- mice, wild-type (WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Il-17a-/- mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes. We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Il-17a-/- mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17A in shaping and regulating the gut microbiota, which conversely, influences the host health.

First Authors:
Yujing Bi
Correspondence:
Guangwei Liu, Nan Qin, Heping Zhang, Ruifu Yang
All Authors:
Yujing Bi, Chunxiao Li, Lin Liu, Jiyuan Zhou, Zhengchao Li, Huimin Deng, Chunyan Wu, Yanping Han, Yajun Song, Yafang Tan, Xiaoyi Wang, Zongmin Du, Yujun Cui, Yanfeng Yan, Fachao Zhi, Guangwei Liu, Nan Qin, Heping Zhang, Ruifu Yang
2017-07-27Article

 



 
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