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张和平+徐健:肉鸡吃益生菌,菌群给力长得快!

时间:2017-08-07 09:49来源:热心肠日报 作者:bio149发布 浏览次数:
    原标题:饲料添加益生菌加快而抗生素减缓肉仔鸡的肠道菌群成熟

    ① 饲料中分别添加益生菌(植物乳杆菌LP-8)和抗生素,在出生到被宰杀的四个时间点,记录肉鸡表型并测定粪便菌群;

    ② 益生菌降低饲料转化率(FCR),诱导最高水平的免疫响应并加速肠道菌群成熟,而抗生素明显阻碍甚至延缓菌群成熟;

    ③ LP-8刺激乳杆菌属细菌生长并促进细菌关联网络的有益变化,抗生素则让菌群属水平间的相互作用更少更弱;

    ④ “肠道菌群成熟指数”或可定量比较饲料添加剂对动物微生态学的影响,益生菌有替代抗生素的巨大潜力。

 
Microbiome
[IF:8.496]
Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken
DOI: 10.1186/s40168-017-0315-1
Abstract:
Background Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Results Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, “intestinal microbiota maturation index” was proposed to quantitatively compare impact of feed additives on animal microecology. Conclusions Our results reveal a tremendous potential of probiotics as antibiotics’ substitute in poultry farming.
First Authors:
Pengfei Gao, Chen Ma, Zheng Sun
Correspondence:
Jian Xu, Heping Zhang
All Authors:
Pengfei Gao, Chen Ma, Zheng Sun, Lifeng Wang, Shi Huang, Xiaoquan Su, Jian Xu, Heping Zhang
2017-08-03Article

 



 
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