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益生菌或可改善抑郁及焦虑

时间:2019-05-13 08:27来源:热心肠日报 作者:沈志勋 浏览次数:
    1.纳入34项对照临床试验进行荟萃分析,研究益生菌及益生元在治疗抑郁及焦虑中的效果;

    2.研究中使用到的益生元包括低聚半乳糖、低聚果糖、短链低聚果糖,以及商品化的Bimuno-低聚半乳糖;

    3.使用到的益生菌多为乳杆菌属及双歧杆菌属菌株;

    4.与安慰剂相比,益生元对于抑郁及焦虑均无显著改善效果;

    5.与安慰剂相比,益生菌对于抑郁及焦虑均有微小但显著的改善效果。

Abstract:
With growing interest in the gut microbiome, prebiotics and probiotics have received considerable attention as potential treatments for depression and anxiety. We conducted a random-effects meta-analysis of 34 controlled clinical trials evaluating the effects of prebiotics and probiotics on depression and anxiety. Prebiotics did not differ from placebo for depression (d = −.08, p = .51) or anxiety (d = .12, p = .11). Probiotics yielded small but significant effects for depression (d = −.24, p < .01) and anxiety (d = −.10, p = .03). Sample type was a moderator for probiotics and depression, with a larger effect observed for clinical/medical samples (d = −.45, p < .001) than community ones. This effect increased to medium-to-large in a preliminary analysis restricted to psychiatric samples (d = −.73, p < .001). There is general support for antidepressant and anxiolytic effects of probiotics, but the pooled effects were reduced by the paucity of trials with clinical samples. Additional randomized clinical trials with psychiatric samples are necessary fully to evaluate their therapeutic potential.

First Authors:
Richard T Liu
Correspondence:
Richard T Liu
All Authors:
Richard T Liu,Rachel F L Walsh,Ana E Sheehan
Article2019-04-17






 
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