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Nature Reviews:后生元的定义和范围(ISAPP共识声明)

时间:2021-05-12 11:49来源:热心肠日报 作者:Echo Quasimodo 浏览次数:
  1.后生元是对宿主健康有益的无生命微生物和/或其成分的制剂;

  2.后生元不是纯化的微生物代谢物和疫苗,但也不限于灭活益生菌;

  3.后生元对目标宿主的有益效应及使用安全性必须得到确认;

  4.后生元的作用机制包括调节常驻菌群、增强上皮屏障功能、调节局部和全身免疫、调节系统代谢和通过神经系统发出系统信号;

  5.后生元的靶点不限于肠道,必须在宿主表面给药,如口腔、肠道、皮肤、泌尿生殖道或鼻咽,注射不属于后生元的范围。

  主编推荐语

  mildbreeze

  后生元(postbiotics)这一术语在科学文献和商业产品中越来越多地出现,但目前仍缺乏明确统一的定义。2019年,国际益生菌和益生元科学协会(ISAPP)召集了专家小组,对后生元的定义和范围进行了审议,并以共识声明的形式于近期在Nature Reviews Gastroenterology and Hepatology上发表,为相关领域的科研、临床、产业和监管从业人员以及消费者,提供了一个“官方”的后生元概念,推荐专业人士仔细阅读。

  Nature Reviews Gastroenterology and Hepatology
[IF:29.848]
  The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics

  国际益生菌和益生元科学协会(ISAPP)关于后生元的定义和范围的共识声明

  10.1038/s41575-021-00440-6

  05-04, Other

  Abstract:收起

  In 2019, the International Scientific Association for Probiotics and Prebiotics (ISAPP) convened a panel of experts specializing in nutrition, microbial physiology, gastroenterology, paediatrics, food science and microbiology to review the definition and scope of postbiotics. The term ‘postbiotics’ is increasingly found in the scientific literature and on commercial products, yet is inconsistently used and lacks a clear definition. The purpose of this panel was to consider the scientific, commercial and regulatory parameters encompassing this emerging term, propose a useful definition and thereby establish a foundation for future developments. The panel defined a postbiotic as a “preparation of inanimate microorganisms and/or their components that confers a health benefit on the host”. Effective postbiotics must contain inactivated microbial cells or cell components, with or without metabolites, that contribute to observed health benefits. The panel also discussed existing evidence of health-promoting effects of postbiotics, potential mechanisms of action, levels of evidence required to meet the stated definition, safety and implications for stakeholders. The panel determined that a definition of postbiotics is useful so that scientists, clinical triallists, industry, regulators and consumers have common ground for future activity in this area. A generally accepted definition will hopefully lead to regulatory clarity and promote innovation and the development of new postbiotic products.

First Authors:

Seppo Salminen

Correspondence Authors:
  
Seppo Salminen

All Authors:

Seppo Salminen,Maria Carmen Collado,Akihito Endo,Colin Hill,Sarah Lebeer,Eamonn M M Quigley,Mary Ellen Sanders,Raanan Shamir,Jonathan R Swann,Hania Szajewska,Gabriel Vinderola




 
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