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张和平团队:乳双歧杆菌V9调节多囊卵巢综合征患者的性激素分泌

时间:2019-04-30 11:10来源:热心肠日报 作者:沈志勋 浏览次数:
    1.多囊卵巢综合征(PCOS)患者的肠道菌群失调,粪杆菌属、双歧杆菌属及布劳特氏菌属的丰度显著降低,而Parabacteroides及梭菌属的丰度显著增加;

    2.在14名PCOS患者中使用益生菌——乳双歧杆菌V9,在9名患者中促黄体激素及促黄体激素/促卵泡素比值显著降低,而性激素及肠道短链脂肪酸显著增加;

    3.在另外5名患者中,乳双歧杆菌V9的作用不明确;

    4.患者体内活性乳双歧杆菌V9的数量与临床指标改善及短链脂肪酸水平升高一致。
 
mSystems [IF:5.75]
Probiotic Bifidobacterium lactis V9 Regulates the Secretion of Sex Hormones in Polycystic Ovary Syndrome Patients through the Gut-Brain Axis
DOI: 10.1128/mSystems.00017-19
Abstract:
Although a few studies have investigated the intestinal microbiota of women with polycystic ovary syndrome (PCOS), the functional and metabolic mechanisms of the microbes associated with PCOS, as well as potential microbial biomarkers, have not yet been identified. To address this gap, we designed a two-phase experiment in which we performed shotgun metagenomic sequencing and monitored the metabolic parameters, gut-brain mediators, and sex hormones of PCOS patients. In the first stage, we identified an imbalance in the intestinal microbiota of the PCOS patients, observing that Faecalibacterium, Bifidobacterium, and Blautia were significantly more abundant in the control group, whereas Parabacteroides and Clostridium were enriched in the PCOS group. In the second stage, we monitored the impact of the probiotic Bifidobacterium lactis V9 on the intestinal microbiome, gut-brain mediators, and sex hormones of 14 PCOS patients. Notably, we observed that the levels of luteinizing hormone (LH) and LH/follicle-stimulating hormone (LH/FSH) decreased significantly in 9 volunteers, whereas the levels of sex hormones and intestinal short-chain fatty acids (SCFAs) increased markedly. In contrast, the changes in the indices mentioned above were indistinct in the remaining 5 volunteers. The results of an analysis of the number of viable Bifidobacterium lactis V9 cells in the two groups were highly consistent with the clinical and SCFA results. Therefore, effective host gut colonization of the probiotic Bifidobacterium lactis V9 was crucial for its ability to function as a probiotic. Finally, we propose a potential mechanism describing how probiotics regulate the levels of sex hormones by manipulating the intestinal microbiome in PCOS patients.
First Authors:
Jiachao Zhang
Correspondence:
Heping Zhang
All Authors:
Jiachao Zhang,Zhihong Sun,Shuaiming Jiang,Xiaoye Bai,Chenchen Ma,Qiannan Peng,Kaining Chen,Haibo Chang,Tuanyu Fang,Heping Zhang
Article2019-04-16





 
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