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张和平团队:干酪乳杆菌Zhang对人肠道菌群的调节具有个体性

时间:2020-04-02 09:00来源:热心肠日报 作者:爱吃番茄的Mona 浏览次数:
    1.纳入6个亚洲地区的106名健康成人,分析食用干酪乳杆菌Zhang(LCZ)对肠道菌群的影响,并计算肠道菌群变异指数(GMVI)进行量化对比;

    2.LCZ对菌群的影响与受试者的基础肠道菌群组成密切相关,且存在地域差异,新疆受试者的GMVI最高、新加坡的最低;

    3.食用LCZ增加了有益菌的相对丰度,抑制了有害菌的生长,且部分受试者肠型改变,使乳酸菌丰度上升;

    4.LCZ可增强菌群的磷酸盐代谢、氨基酸转运系统和异亮氨酸生物合成,降低脂多糖生物合成。

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    内蒙古农业大学张和平团队研究成果。文章采用PacBio单分子实时测序技术,测定了食用干酪乳杆菌Zhang(LCZ)对6个不同亚洲地区健康成人的肠道菌群的影响。研究结果表明,LCZ对菌群的影响高度依赖个体本身的菌群组成,并揭示了LCZ对肠道菌群的组成和功能的潜在有益调节作用。这些发现对于益生菌的精准化应用具有重要参考意义。

    注:本研究的原文信息和链接出处,以及相关解读和评论文章。欢迎读者朋友们推荐!

    Gut Microbes            [IF:7.823]

    Probiotic-directed modulation of gut microbiota is basal microbiome dependent

    益生菌对肠道菌群的直接调节依赖于基础菌群

    10.1080/19490976.2020.1736974    03-21, Article

Abstract:
As an effective means to improve quality of life and prevent diseases, the demand for probiotics and related products has increased in recent years. However, it is still unclear whether a particular probiotic strain will have similar beneficial effects on healthy adults from different regions. In this study, the probiotic Lactobacillus casei Zhang (LCZ) was consumed by healthy adults from six different Asian regions and the changes in gut microbiota were compared using PacBio single molecule, real-time (SMRT) sequencing technology based on samples collected before, during and after consumption of LCZ. Our results reveal that the effect of LCZ consumption on individuals was closely related to the composition of that individual’s basal gut microbiota. A Gut Microbiota Variability Index (GMVI) was proposed to quantitatively compare the effects of LCZ on human gut microecology. Subjects from Xinjiang and Singapore regions had the highest and lowest GMVI, respectively. In general, consumption of LCZ increased the relative abundance of certain beneficial bacteria such as Lactobacillus, Roseburia, Coprococcus and Eubacterium rectale, while it inhibited growth of certain harmful bacteria such as Blautia and Ralstonia pickettii. In addition, consumption of LCZ was responsible for the conversion of some participants from Prevotella copri/Faecalibacterium prausnitzii (PF) enterotype to Faecalibacterium prausnitzii/Bacteroides dorei (FB) enterotype and consistently increased the abundance of lactic acid bacteria in the gut. It also increased/enhanced phosphate metabolic modules, amino acid transport systems, and isoleucine biosynthesis, but conversely decreased lipopolysaccharide biosynthesis. These changes could have health benefits for healthy adults.
First Authors:
Qiangchuan Hou,Feiyan Zhao
Correspondence Authors:
Heping Zhang
All Authors:
Qiangchuan Hou,Feiyan Zhao,Wenjun Liu,Ruirui Lv,Wei Wei Thwe Khine,Jia Han,Zhihong Sun,Yuan-Kun Lee,Heping Zhang





 
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